Proanthocyanidins are plant biochemicals called polyphenols. “Grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure in middle-aged women.” What are Proanthocyanidins? A loss of muscle mass often accompanies menopausal symptoms. In addition, the was a reduction in anxiety and depression scores, and a reduction of blood pressure among both grape seed extract groups.įurthermore, muscle mass increased in both grape seed extract groups during the eight week treatment.
The high-proanthocyanidin group also scored significantly better on insomnia scores after the eight weeks treatment. The groups taking the grapeseed extract had significantly fewer general menopause symptoms and fewer hot flashes at the end of the study. The researchers also measured heart and metabolic factors as well. They measured these symptoms at the beginning of the study, after four weeks and after eight weeks of the treatment. The researchers utilized the Menopausal Health-Related Quality of Life Questionnaire and the Hospital Anxiety and Depression Scale, along with the Athens Insomnia Scale to gauge the patients’ symptoms. The researchers divided the women and gave one group a placebo, and the other group was given grape seed extract with either 100 milligrams per day of proanthocyanidins or 200 milligrams per day of proanthocyanidins. Each of the women had at least one symptom of menopause. They were each between 40 and 60 years old.
The researchers, from the Tokyo Medical and Dental University, conducted a placebo-controlled, double-blind and randomized study of 91 women.
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